Association between the NBS1 Glu185Gln polymorphism and lung cancer risk: a systemic review and meta-analysis

作者：Wang, Lixin; Cheng, Jinsong; Gao, Jinyu^*; Wang, Jipeng; Liu, Xiaoning; Xiong, Liwen

来源：Molecular Biology Reports, 2013, 40(3): 2711-2715.

DOI：10.1007/s11033-012-2358-5

• NBS1
• Lung cancer
• Polymorphism
• Meta-analysis

Nijmegen Breakage Syndrome protein 1 (NBS1) is one of the most important DNA repair proteins playing important roles in maintaining the genomic stability of NDA. Previous studies regarding the association between NBS1 8360G > C (Glu185Gln) polymorphism and lung cancer reported conflicting results. To derive a more precise estimation of this association, a systemic review and meta-analysis was performed. We performed a meta-analysis using eligible case-control studies to summarize the data on the association between the NBS1 Glu185Gln polymorphism and lung cancer risk. Odds ratios (ORs) with corresponding 95 % confidence intervals (95 %CIs) were pooled to assess the association between NBS1 Glu185Gln polymorphism and lung cancer risk. Six case-control studies with a total of 2,348 lung cancer cases and 2,401 controls without canner were included into the meta-analysis. Overall, there was an association between NBS1 Glu185Gln polymorphism and lung cancer risk under the dominant comparison model (fixed-effects OR (GluGln/GlnGln vs. GluGlu) = 1.21, 95 % CI 1.07-1.37, P = 0.002, I (2) = 8.1 %). Subgroup analysis by race suggested a significant association between NBS1 Glu185Gln polymorphism and lung cancer risk in Asians (fixed-effects OR (GluGlnGlnGln vs. GluGlu) = 1.22, 95 % CI 1.06-1.41, P = 0.005) but not in Caucasians (fixed-effects OR (GluGlnGlnGln vs. GluGlu) = 1.17, 95 % CI 0.91-1.50, P = 0.220). This meta-analysis supports that there is an association between NBS1 Glu185Gln polymorphism and lung cancer risk. More studies are needed to further verify this association.

• 出版日期2013-3
• 单位南京医科大学; 上海交通大学