Central Venous Oxygen Saturation: A Potential New Marker for Circulatory Stress in Haemodialysis Patients?

作者：Harrison Laura E A; Selby Nicholas M^*; McIntyre Christopher W

来源：Nephron Clinical Practice, 2014, 128(1-2): 57-60.

DOI：10.1159/000362557

• Central venous oxygenation
• Circulatory stress
• Haemodialysis
• Ultrafiltration volume

Background/Aims: Haemodialysis causes recurrent haemodynamic stress with subsequent ischaemic end-organ dysfunction. As dialysis prescriptions/schedules can be modified to lessen this circulatory stress, an easily applicable test to allow targeted interventions in vulnerable patients is urgently required. Methods: Intra-dialytic central venous oxygen saturation (ScvO(2)) and clinical markers (including ultrafiltration, blood pressure) were measured in 18 prevalent haemodialysis patients. Results: Pre-dialysis ScvO(2) was 63.5 +/- 13% and fell significantly to 56.4 +/- 8% at end dialysis (p = 0.046). Ultrafiltration volume, a key driver of dialysis-induced myocardial ischaemia, inversely correlated to ScvO(2) (r = -0.680, p = 0.015). Conclusions: This initial study demonstrates ScvO(2) sampling is practical, with a potential clinical utility as an indicator of circulatory stress during dialysis.

• 出版日期2014-12