Degradation of antineoplastic cytarabine in aqueous phase by advanced oxidation processes based on ultraviolet radiation

作者：Ocampo Perez R; Sanchez Polo M; Rivera Utrilla J^*; Leyva Ramos R

来源：Chemical Engineering Journal, 2010, 165(2): 581-588.

DOI：10.1016/j.cej.2010.09.076

• Cytarabine
• UV radiation
• Advanced oxidation processes
• H(2)O(2)
• K(2)S(2)O(8)

The aim of this study was to determine the effectiveness of oxidation processes based on cytarabine degradation using UV radiation (UV, UV/H(2)O(2), and UV/K(2)S(2)O(8)). Results show that UV radiation alone is not effective to remove cytarabine from the aqueous medium, due to the low quantum yield of this molecule (Phi(lambda) =6.88 x 10(-6) mol Einstein(-1)). The addition of H(2)O(2) or K(2)S(2)O(8) considerably increased the removal effectiveness due to the generation of HO(center dot) and SO(4)(center dot-) radicals. The reaction rate constants between cytarabine and HO(center dot) radicals and SO(4)(center dot-) radicals were k(HO center dot cyst) = 3.15 x 10(10) m(-1) s(-1) and k(SO4 center dot-cyt) = 1.61 x 10(9) M(-1) s(-1). For both systems (UV/H(2)O(2) and UV/K(2)S(2)O(8)), (i) an decrease in the pH of solution reduces the cytarabine removal rate, (ii) a specific concentration of H(2)O(2) and K(2)S(2)O(8) produces the highest cytarabine removal rate, (iii) the chemical composition of water considerably affects the cytarabine oxidation rate, especially in the UV/H(2)O(2) system, mainly clue to the lesser selectivity and greater reactivity of the HO(center dot) radical, and (iv) the total organic carbon concentration in the medium decreased with longer treatment time but the toxicity increased, especially in the case of the UV/H(2)O(2) system.

• 出版日期2010-12-1