Age-independent association between arterial and bone remodeling in mild-to-moderate chronic kidney disease

作者：Briet Marie^*; Maruani Gerard; Collin Cedric; Bozec Erwan; Gauci Cedric; Boutouyrie Pierre; Houillier Pascal; Laurent Stephane; Froissart Marc

来源：Nephrology Dialysis Transplantation, 2010, 25(1): 191-197.

DOI：10.1093/ndt/gfp373

• arterial remodeling
• arterial stiffness
• bone mineral density
• chronic kidney disease
• echotracking

Methods. One hundred and seven patients (60.4 +/- 14.6 years) with CKD (mean glomerular filtration rate = 34 +/- 17 mL/min/1.73 m(2)) were included in this cross-sectional study. Common carotid artery diameter, intima-media thickness and carotid stiffness were determined with an echotracking system. Bone evaluation was performed by bone densitometry and the measurement of a bone-remodeling marker, bone-specific alkaline phosphatase (BSALP).
Results. After adjustment for age, sex, mean blood pressure, carotid pulse pressure and glomerular filtration rate, bone mineral densities measured at the radius, hip and lumbar spine were significantly and negatively correlated with carotid internal diameter (P = 0.0001, P = 0.0003, P = 0.01, respectively). This association exists only in patients with glomerular filtration rate < 38 mL/min/ 1.73 m(2). BSALP was independently and positively correlated with carotid internal diameter and explained 13% of the variance.
Conclusions. Bone mineral density and serum marker of bone remodeling are independently correlated with arterial remodeling in CKD patients suggesting a crosstalk between kidney, arterial wall and bone.

• 出版日期2010-1