Upregulation of thyroid transcription factor-1 and human leukocyte antigen class I in Hashimoto's disease providing a clinical evidence for possible triggering autoimmune reaction

作者：Huang, Huibin; Li, Xisheng; Lin, Ling^*; Shi, Yaxiong; Lin, Xiahong; Li, Liangyi; Xu, Dongming

来源：European Journal of Endocrinology, 2011, 164(5): 795-800.

DOI：10.1530/EJE-10-0960

• COMPLEX CLASS-I
• SYSTEMIC-LUPUS-ERYTHEMATOSUS
• TSH-RECEPTOR EXPRESSION
• GENE-EXPRESSION
• GRAVES-DISEASE
• FOLLICULAR THYROGLOBULIN
• MICE
• IODIDE
• METHIMAZOLE
• CELLS

Objective: An increase in the expression of autoantigens and their presenting molecules human leukocyte antigen (HLA) class I has been demonstrated to be responsible for autoimmune diseases. Thyroid transcription factor-1 (TTF-1 or NKX2-1) synchronously upregulates both HLA class I and thyroid-specific autoantigen, which may be involved in the pathological process of autoimmune thyroiditis. In this study, the expressions and potential role of TTF-1 and HLA class I in Hashimoto's disease (HT) were examined.
Patients: In this study, 22 resection specimens clinically and histopathologically confirmed to have Hashimoto's disease and 30 normal thyroid specimens from adjacent tissues of thyroid adenoma were used.
Measurement: Western blot, real-time PCR, and immunohistochemistry were performed to assay TTF-1 and HLA class I in the thyrocytes of Hashimoto's disease as well as in the normal thyroid from adjacent tissues of thyroid adenoma. Results: The TTF-1 and HLA class I in Hashimoto's disease were significantly higher than those in the controls.
Conclusion: Upregulation of TTF-1 and HLA class I in Hashimoto's disease provide a clinical evidence for possible triggering of autoimmune reaction.

• 出版日期2011-5
• 单位福建医科大学