Disruption of Ion Homeostasis by Verrucosin and a Related Compound

作者：Akiyama Koichi; Tone Junichi; Yamauchi Satoshi; Sugahara Takuya; Maruyama Masafumi; Kakinuma Yoshimi^*

来源：Bioscience Biotechnology and Biochemistry, 2011, 75(5): 1000-1002.

DOI：10.1271/bbb.110004

• lignan
• verrucosin
• ion homeostasis
• ionophore

We have found that (-)-virgatusin and related compounds have antimicrobial and antifungal activity. To identify further biological activities of these compounds, we tested the activity of acridine orange efflux, which shows ionophore-like disruption of cellular ion homeostasis activity. After testing 31 compounds, we found that verrucosin and a related compound had disruption activity.

• 出版日期2011-5