A Tractable and Efficient One-Pot Synthesis of 5 '-Azido-5 '-deoxyribonucleosides

作者：Peterson Theodore V; Streamland Tobin U B; Awad Ahmed M^*

来源：Molecules, 2014, 19(2): 2434-2444.

DOI：10.3390/molecules19022434

• modified nucleosides
• 5 '-azido nucleosides
• Appel reaction
• Mitsunobu reaction
• antisense oligonucleotides
• ribonucleic guanidine (RNG)

Synthetic routes to 5'-azidoribonucleosides are reported for adenosine, cytidine, guanosine, and uridine, resulting in a widely applicable one-pot methodology for the synthesis of these and related compounds. The target compounds are appropriate as precursors in a variety of purposive syntheses, as the synthetic and therapeutic relevance of azido-and amino-modified nucleosides is expansive. Furthermore, in the conversion of alcohols to azides, these methods offer a tractable alternative to the Mitsunobu and other more difficult reactions.

• 出版日期2014-2