Antihyperglycemic and Antioxidant Effects of Flesh and Peel from Pomace of Viburnum dilatatum on Normal and Diabetic Mice

作者：Iwai Kunihisa; Onodera Akio; Iwai Kayo; Morinaga Yae; Matsue Hajime

来源：Journal of the Japanese Society for Food Science and Technology, 2011, 58(9): 413-420.

• Viburnum dilatatum pomace
• flesh and peel
• antihyperglycemic activity
• antioxidant effect
• diabetic mouse

The antihyperglycemic and antioxidant effects of flesh and peel powder, which were isolated from the pomace of Viburnum dilatatum fruit (VPFPP), were investigated in normal and diabetic mice in order to find methods of utilizing this previously unused resource and to reduce waste. There were no negative effects on the growth and plasma biochemistries of mice that were fed a 1% VPFPP-containing diet for four weeks. Normal mice fed VPFPP did not show any elevation of non-fasting plasma glucose level. However, when VPFPP was fed to KK-A(y) mice, a type 2 diabetic model mouse, the mice showed a dose-dependent suppression of increasing plasma glucose and insulin levels. When sucrose was administered orally into the fasted mice, a dose-dependent suppression of elevating plasma glucose concentration was also found in the KK-A(y) mice that were fed VPFPP diets. It was considered that these inhibitory effects were induced by the a-glucosidase inhibitory activity of polyphenols and the large amount of dietary fiber contained in VPFPP. Moreover, increase of plasma lipid peroxidation was suppressed by VPFPP ingestion in KK-A(y) mice. These results suggested that the flesh and peel from the pomace of V. dilatatum might be a new functional material with antioxidant and antihyperglycemic potencies. (Received Mar. 25, 2011; Accepted May 23, 2011)

• 出版日期2011