科研之友
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摘要
A series of salicylaldehyde-2-pyridinehydrazone derivatives were found to exhibit interesting "turnon" fluorescence response toward Zn2+ in water at neutral pH, which could be prepared readily from commercially available materials through a one-step reaction in ethanol at room temperature. Among these compounds, 1 showed a 22-fold fluorescence enhancement in 99% water/DMSO (v/v) at pH 7.0 with a linear range of 0.10-1.00 mu mol/L and detection limit of 30 nmol/L Zn2+. Especially, 1 was not affected by Cd2+ which usually induced a comparable fluorescence response to that of Zn2+ in other reported works. Moreover, live cell imaging showed that 1 could be useful for monitoring Zn2+ within biological samples.
- 出版日期2013-7-31
- 单位清华大学
