A Gram-Scale Batch and Flow Total Synthesis of Perhydrohistrionicotoxin

作者：Brasholz Malte; Macdonald James M; Saubern Simon; Ryan John H^*; Holmes Andrew B

来源：Chemistry - A European Journal, 2010, 16(37): 11471-11480.

DOI：10.1002/chem.201001435

• alkaloids
• cycloaddition
• flow chemistry
• olefination
• total synthesis

The total synthesis of the spiropiperidine alkaloid (-)-perhydrohistrionicotoxin (perhydro-HTX) 2 has been accomplished on a gram scale by employing both conventional batch chemistry as well as microreactor techniques. (S)-(-)-6-Pentyltetrahydropyran-2-one 8 underwent nucleophilic ring opening to afford the alcohol 10, which was elaborated to the nitrone 13. Protection of the nitrone as the 1,3-adduct of styrene and side-chain extension to the unsaturated nitrile afforded a precursor 17, which underwent dipolar cycloreversion and 1,3-dipolar cycloaddition to give the core spirocyclic precursor 18 that was converted into perhydro-HTX 2. The principal steps to the spirocycle 18 have successfully been transferred into flow mode by using different types of microreactors and in a telescoped fashion, allowing for a more rapid access to the histrionicotoxins and their analogues by continuous processing.

• 出版日期2010
• 单位CSIRO