An Assessment of Amplicon-Sequencing Based Method for Viral Intrahost Analysis

作者：Ni, Ming; Chen, Chen; Liu, Di^*

来源：VIROLOGICA SINICA, 2018, 33(6): 557-560.

DOI：10.1007/s12250-018-0052-z

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<正>Dear Editor,RNA virus features the high per-generation mutation rate,resulting in highly diversified population, which determines viral phenotypes and fitness (Domingo et al. 2012).The development of deep sequencing and bioinformatic techniques paves the way to study viral population genetics at an intrahost level, and has provided new insights into

• 出版日期2018-12
• 单位中国科学院武汉病毒研究所; 首都医科大学; 北京地坛医院; 北京中医药大学