A single dose of a non-steroidal anti-inflammatory drug (NSAID) prevents severe pain after ureteric stent removal: a prospective, randomised, double-blind, placebo-controlled trial

作者：Tadros Nicholas N; Bland Lisa; Legg Edith; Olyaei Ali; Conlin Michael J^*

来源：BJU International, 2013, 111(1): 101-105.

DOI：10.1111/j.1464-410X.2012.11214.x

• ureteroscopy
• stents
• urolithiasis
• NSAIDs

Objectives To determine the incidence of severe pain after ureteric stent removal. %26lt;br%26gt;To evaluate the efficacy of a single dose of a non-steroidal anti-inflammatory drug (NSAID) in preventing this complication. %26lt;br%26gt;Patients and Methods %26lt;br%26gt;A prospective, randomised, double-blind, placebo-controlled trial was performed at our institution. %26lt;br%26gt;Adults with an indwelling ureteric stent after ureteroscopy were randomised to receive either a single dose of placebo or an NSAID (rofecoxib 50 mg) before ureteric stent removal. %26lt;br%26gt;Pain was measured using a visual analogue scale (VAS) just before and 24 h after stent removal %26lt;br%26gt;Pain medication use after ureteric stent removal was measured using morphine equivalents. %26lt;br%26gt;Results %26lt;br%26gt;In all, 22 patients were enrolled and randomised into the study before ending the study after interim analysis showed significant decrease in pain level in the NSAID group. %26lt;br%26gt;The most common indication for ureteroscopy was urolithiasis (14 patients). %26lt;br%26gt;The proportion of patients with severe pain (VAS score of %26gt;= 7) during the 24 h after ureteric stent removal was six of 11 (55%) in the placebo group and it was zero of 10 in the NSAID group (P %26lt; 0.01). %26lt;br%26gt;There were no complications related to the use of rofecoxib. %26lt;br%26gt;Conclusions %26lt;br%26gt;We found a 55% incidence of severe pain after ureteric stent removal. %26lt;br%26gt;A single dose of a NSAID before stent removal prevents severe pain after ureteric stent removal.

• 出版日期2013-1