A Phosphine-Catalyzed Preparation of 4-Arylidene-5-imidazolones

作者:Gabillet Sandra; Loreau Olivier; Specklin Simon; Rasalofonjatovo Evelia; Taran Frederic*
来源:Journal of Organic Chemistry, 2014, 79(20): 9894-9898.
DOI:10.1021/jo501922j

摘要

A simple and efficient method for constructing 4-arylidene-S-imidazolones was developed using a phosphine-catalyzed tandem umpolung addition and intramolecular cyclization of amidine pronucleophiles on arylpropiolates. The reaction offers a robust route to heterocycle analogues of the fluorescent protein chromophores.

  • 出版日期2014-10-17
  • 单位中国地震局