科研之友
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摘要
Cyanomethylation of chiral N-(tert-butylsulfinyl)imines with 2-trimethylsilylacetonitrile (TMSCH2CN) in the presence of a Lewis base such as tetrabutylammonium phenoxide (PhONn-Bu-4) proceeds smoothly to afford the corresponding beta-amino nitriles in good to high yields with excellent diastereoselectivities.
- 出版日期2007-10-5
