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摘要
Objective: To evaluate the association between markers of vitamins B12, B6 and folate deficiency and the geriatric syndrome of frailty. Design: Cross-sectional study of baseline measures from the combined Women's Health and Aging Studies. Setting: Baltimore, Maryland. Participants: Seven hundred three community-dwelling women, aged 70-79. Measurements: Frailty was defined by five-component screening criteria that include weight, grip strength, endurance, physical activity and walking speed measurements and modeled as binary and 3-level polytomous outcomes. Independent variables serum vitamin B6, vitamin B12, methylmalonic acid, total homocysteine, cystathionine and folate were modeled continuously and as abnormal versus normal. Results: Serum biomarker levels varied significantly by race. All analyses were race-stratified and results are reported only for Caucasian women due to small African American sample size. In polytomous logistic regression models of 3-level frailty, Caucasian women with increasing MMA, defined either continuously or using a predefined threshold, had 40-60% greater odds of being prefrail (p-values < 0.07) and 1.66-2.33 times greater odds of being frail (p-values < 0.02) compared to nonfrails after adjustment for age, education, low serum carotenoids, alcohol intake, cardiovascular disease and renal impairment. Both binary and polytomous frailty models evaluating vitamin B 12 as the main exposure estimated odds ratios that were similar in trend yet slightly less significant than the MMA results. Conclusions: These results suggest that vitamin B12 deficiency may contribute to the frailty syndrome in community-dwelling older women. Future studies are needed to explore these relationships longitudinally.
- 出版日期2008-5
