A meta-analysis of randomized double-blind clinical trials in CMT1A to assess the change from baseline in CMTNS and ONLS scales after one year of treatment

作者：Mandel Jonas^*; Bertrand Viviane; Lehert Philippe; Attarian Shahram; Magy Laurent; Micallef Joelle; Chumakov Ilya; Scart Gres Catherine; Guedj Mickael; Cohen Daniel

来源：Orphanet Journal of Rare Diseases, 2015, 10(1): 74.

DOI：10.1186/s13023-015-0293-y

• Charcot-Marie-Tooth
• CMT1A
• CMTNS
• ONLS
• PXT3003
• Meta-analysis
• Ascorbic acid
• Clinical trials
• Randomized
• Double blind

CMT1A is the most common inherited peripheral neuropathy. There is currently no approved treatment. We performed a meta-analysis including four randomized, double-blind, Placebo-controlled clinical trials to assess the disease progression after one year under Placebo, Ascorbic Acid (AA) or PXT3003, a combination of three repurposed drugs. We observed a weak deterioration in patients under Placebo, well below the reported natural disease progression. Patients treated with AA were stable after one year but not significantly different from Placebo. Patients undergoing PXT3003 treatment showed an improvement in CMTNS and ONLS, statistically significant versus Placebo and potentially precursory of a meaningful change in the disease course.

• 出版日期2015-6-13