High-performance dendritic contrast agents for X-ray computed tomography imaging using potent tetraiodobenzene derivatives

作者：You Suyeon; Jung Hye youn; Lee Chaewoon; Choe Yun Hui; Heo Ju Young; Gang Gil Tae; Byun Sang Kyung; Kim Won Kon; Lee Chul Ho; Kim Dong Eog; Kim Young Il; Kim Yoonkyung

来源：Journal of Controlled Release, 2016, 226: 258-267.

DOI：10.1016/j.jconrel.2016.01.036

• Dendrimers
• Computed tomography
• In vivo imaging
• Iodinated contrast agents
• Nanomedicine

The use of computed tomography (CT) for vascular imaging is critical in medical emergencies requiring urgent diagnostic decisions, such as cerebral ischemia and many cardiovascular diseases. Small-molecule iodinated contrast media are often injected intravenously as radiopaque agents during CT imaging to achieve high contrast enhancement of vascular systems. The rapid excretion rate of these agents is overcome by injecting a significantly high dose of iodine, which can have serious side effects. Here we report a simple method to prepare blood-pool contrast agents for CT based on dendrimers for the first time using tetraiodobenzene derivatives as potent radiopaque moieties. Excellent in vivo safety has been demonstrated for these small (13-22nm) unimolecular water-soluble dendritic contrast agents, which exhibit high contrast enhancement in the blood-pool and effectively extend their blood half-lives. Our method is applicable to virtually any scaffold with suitable surface groups and may fulfill the current need for safer, next-generation iodinated CT contrast agents.

• 出版日期2016-3-28