Double spiral detection channel for on-chip chemiluminescence detection

作者：Lok Khoi Seng; Kwok Yien Chian; Nam Trung Nguyen^*

来源：Sensors and Actuators B: Chemical , 2012, 169: 144-150.

DOI：10.1016/j.snb.2012.04.047

• Chemiluminescence
• Lab-on-chip
• Micro total analysis system
• Luminol
• Cobalt
• L-Cysteine
• Uric acid

In this paper, we introduced a three-layered microchip that consists of a double spiral channel design for chemiluminescence (CL) detection and a passive micromixer to facilitate the mixing of reagents. The design with two overlapping spiral channels doubled the CL intensity emitted from the reaction as compared to the design with a single spiral channel. The addition of the passive micromixer improved the signal by 1.5 times. Luminol-based chemiluminescence reaction was used for the characterization of the device. This microchip was successfully tested with the determination of L-cysteine and uric acid.

• 出版日期2012-7-5
• 单位南阳理工学院