A smart drug: a pH-responsive photothermal ablation agent for Golgi apparatus activated cancer therapy

作者:Xue, Fengfeng; Wen, Ying; Wei, Peng; Gao, Yilin; Zhou, Zhiguo; Xiao, Shuzhang; Yi, Tao*
来源:Chemical communications, 2017, 53(48): 6424-6427.
DOI:10.1039/c7cc03168h

摘要

We report a pH-responsive photothermal ablation agent (pH-PTT) based on cyanine dyes for photothermal therapy (PTT). The nano-particles formed by BSA and pH-PTT preferentially accumulated in the Golgi apparatus of cancer cells compared to normal cells, and thus can be specifically activated by the acidic Golgi apparatus in cancer cells for effective PTT both ex vivo and in vivo.