A probabilistic model for the carry-over of PCDD/Fs from feed to growing pigs

作者：Adolphs Julian^*; Kleinjung Frank; Numata Jorge; Mielke Hans; Abraham Klaus; Schafft Helmut; Mueller Graf Christine; Greiner Matthias

来源：Chemosphere, 2013, 93(3): 474-479.

DOI：10.1016/j.chemosphere.2013.06.015

• PCDD/F
• Growing pigs
• Carry-over
• Kinetic model
• Monte-Carlo simulation

When food producing animals are contaminated with PCDD/F congeners, information on the contaminant%26apos;s concentration in the bodies of the animals at time of slaughter is needed for risk management purposes. We have developed a mathematical model for the kinetics of PCDD/Fs in growing pigs in case of contaminated feed fed for a limited duration of time. This model allows the prediction of concentrations in body fat. It considers absorption fractions of PCDD/Fs, clearance by metabolism, dilution by growth and excretion through fecal fat. The model parameters were calibrated by fitting the model to experimental data. On the basis of this toxicokinetic model a probabilistic model has been constructed. The probabilistic model handles the parameters with appropriate probability distributions and Monte-Carlo simulation technique, providing for realistic situations with many animals and a range of contaminations and feeding intervals. We applied the new model to describe the German dioxin incident of winter 2010/2011 and discuss its viability as decision tool. The approach demonstrated here is a showcase how a risk assessment in the case of contaminated feeding can be performed.

• 出版日期2013-9