A novel technique for simultaneous diagnosis and radioprotection by radioactive cerium oxide nanoparticles: study of cyclotron production of Ce-137m

作者：Bakht Mohamadreza K; Sadeghi Mahdi^*; Tenreiro Claudio

来源：Journal of Radioanalytical and Nuclear Chemistry, 2012, 292(1): 53-59.

DOI：10.1007/s10967-011-1483-2

• Ce-137m
• Cerium oxide nanoparticle (CNP)
• Cyclotron production
• Nuclear medicine
• Radioprotection

Application of nanoparticles in nuclear medicine has aimed to develop diagnosis and therapeutic techniques. Cerium oxide nanoparticles (CNPs) are expected to be useful for protection of healthy tissue from radiation-induced harm and could serve therapeutic function. Among a variety of cerium radioisotopes, Ce-137m (T (1/2) = 34.4 h, IT (99.22%), beta(+) (0.779%)) could be a novel candidate radionuclide in the field of diagnosis owing to its appropriate half-life, 99.91% natural abundance of target and its intense gamma line at 254.29 keV. In this study, Ce-137m excitation function via the La-nat(p,3n) reaction was calculated by TALYS-1.2 and EMPIRE-3 codes. The excitation function calculations demonstrated that the La-nat(p,3n)Ce-137m reaction leads to the formation of the Ce-136/138 isotopic contamination in the 22-35 MeV energy range. Interestingly, the isotopic impurities of Ce-137m could serve radio protector function. Overall results indicate that the cyclotron produced (CeO2)-Ce-137m nanoparticles by irradiation of a target encompassing lanthanum oxide nanoparticles could be a potent alternative for conventional diagnostic radionuclides with simultaneous radioprotection capacity.

• 出版日期2012-4