Acetylene functionalized BODIPY dyes and their application in the synthesis of activity based proteasome probes

作者：Verdoes Martijn; Hillaert Ulrik; Florea Bogdan I; Sae Heng Myra; Risseeuw Martijn D P; Filippov Dmitri V; van der Marel Gij**ert A; Overkleeft Herman S^*

来源：Bioorganic & Medicinal Chemistry Letters, 2007, 17(22): 6169-6171.

DOI：10.1016/j.bmc1.2007.09.025

• fluorophore
• proteasome
• inhibitor
• bioconjugate

The synthesis of three acetylene functionalized BODIPY dyes is described. These dyes are used to fluorescently modify an azido functionalized epoxomicin analogue employing the Huisgen 1,3-dipolar cycloaddition, resulting in a panel of fluorescent epoxomicin derived proteasome probes.

• 出版日期2007-11-15