Modification of titanium surface with collagen and doxycycline as a new approach in dental implants

作者：Corobea Marijana Simina; Albu Madalina Georgiana; Ion Raluca; Cimpean Anisoara; Miculescu Florin; Antoniac Iulian Vasile; Raditoiu Valentin; Sirbu Ioan; Stoenescu Mihai; Voicu Stefan Ioan^*; Ghica Mihaela Violeta

来源：Journal of Adhesion Science and Technology, 2015, 29(23): 2537-2550.

DOI：10.1080/01694243.2015.1073661

• titanium
• collagen
• doxycycline
• drug delivery
• osseointegration

In this work, we investigate for the first time several issues involved in bio-adhesion process for a new type of chemically modified titanium surfaces (in their initial form and after collagen deposition), in order to assess their potential in dental implant surface modification. For this purpose, we studied the following: collagen adhesion, cytotoxicity, osteoblast cytomorphology, cell adhesion and proliferation, doxycycline embedding and modifications in the collagen film deposed on the metal surfaces, drug release from the collagen films. The improvement of adhesion between collagen film and titanium substrate, when hydroxyl and amino functional groups are assisting the surfaces was presented, all materials showing no cytotoxic effects as revealed by lactate dehydrogenase-based assay. The drug release from titanium-coll-doxy systems offers a dual mechanism of the delivery profile (burst release followed by moderate discharge of the antibiotic), with perspectives in soft tissue recovery postoperative stage.

• 出版日期2015-12-2