Atypical Progressive Multifocal Leukoencephalopathy in a Patient with Antisynthetase Syndrome

作者：Belhassen Garcia Moncef^*; Rabano Gutierrez Alberto; Velasco Tirado Virginia; Romero Alegria Angela; Perez Garcia Maria Luisa; Martin Oterino Jose Angel

来源：Internal Medicine, 2015, 54(5): 519-524.

DOI：10.2169/internalmedicine.54.2748

• Anti-Jo-1
• antisynthetase syndrome
• rituximab
• progressive multifocal leukoencephalopathy
• JC virus

Antisynthetase syndrome is a disorder belonging to the dermatomyositis/polymyositis group, with high rates of morbidity and mortality. We herein present the case of a 71-year-old man who was diagnosed with antisynthetase syndrome and treated with rituximab. Almost three years later, the patient showed right-sided hemiparesis that ultimately progressed to complete hemiplegia and advancing cognitive deterioration with a poor clinical outcome. The neuropathological diagnosis was progressive multifocal leukoencephalopathy. Treatment with rituximab for antisynthetase syndrome itself plays a fundamental role in the development of infectious complications.

• 出版日期2015