Anti-NMDAR encephalitis followed by seropositive neuromyelitis optica spectrum disorder: A case report and literature review

作者：Ran, Ye; Wang, Lu; Zhang, Fangfang; Ao, Ran; Dong, Zhao^*; Yu, Shengyuan^*

来源：Clinical Neurology and Neurosurgery, 2017, 155: 75-82.

DOI：10.1016/j.clineuro.2017.02.016

• Anti-NMDAR antibodies
• Encephalitis, NMOSD
• AQP4-IgG

Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory central nervous system syndrome, and encephalitis associated with anti-N-methyl-o-aspartate receptor (NMDAR) antibodies is an autoimmune encephalopathy. A patient with both diseases, separately or simultaneously, is rare as a clinical phenomenon, but cannot be ignored. We report the clinical characteristics and imaging features of a special case with anti-NMDAR encephalitis followed by NMOSD. We subsequently reviewed the English language literature about demyelinating disorders with anti-NMDAR encephalitis. Details of the 34 patients identified are summarized and compared. There may be a connection between anti-NMDAR encephalitis and NMOSD.

• 出版日期2017-4
• 单位中国人民解放军总医院