Automatic sorting of toxicological information into the IUCLID (International Uniform Chemical Information Database) endpoint-categories making use of the semantic search engine Go3R

作者：Sauer Ursula G; Wachter Thomas; Hareng Lars; Wareing Britta; Langsch Angelika; Zschunke Matthias; Alvers Michael R; Landsiedel Robert^*

来源：Toxicology in Vitro, 2014, 28(4): 571-587.

DOI：10.1016/j.tiv.2013.12.011

• Semantic search engine
• REACH
• Registration dossiers
• Regulatory toxicology
• Data sharing
• Alternative methods
• 3Rs principle

The knowledge-based search engine G03R, www.Go3R.org, has been developed to assist scientists from industry and regulatory authorities in collecting comprehensive toxicological information with a special focus on identifying available alternatives to animal testing. The semantic search paradigm of Go3R makes use of expert knowledge on 3Rs methods and regulatory toxicology, laid down in the ontology, a network of concepts, terms, and synonyms, to recognize the contents of documents. Search results are automatically sorted into a dynamic table of contents presented alongside the list of documents retrieved. This table of contents allows the user to quickly filter the set of documents by topics of interest. Documents containing hazard information are automatically assigned to a user interface following the endpoint-specific IUCLID5 categorization scheme required, e.g. for REACH registration dossiers. For this purpose, complex endpoint-specific search queries were compiled and integrated into the search engine (based upon a gold standard of 310 references that had been assigned manually to the different endpoint categories). G03R sorts 87% of the references concordantly into the respective IUCLID5 categories. Currently, G03R searches in the 22 million documents available in the PubMed and TOXNET databases. However, it can be customized to search in other databases including in-house databanks.

• 出版日期2014-6