Dynamic Functional Connectivity Reveals Altered Variability in Functional Connectivity Among Patients With Major Depressive Disorder

作者：Demirtas Murat^*; Tornador Cristian; Falcon Carles; Lopez Sola Marina; Hernandez Ribas Rosa; Pujol Jesus; Menchon Jose M; Ritter Petra; Cardoner Narcis; Soriano Mas Carles; Deco Gustavo

来源：Human Brain Mapping, 2016, 37(8): 2918-2930.

DOI：10.1002/hbm.23215

• mood disorders
• major depressive disorder
• dynamic functional connectivity
• resting state
• fMRI

Resting-state fMRI (RS-fMRI) has become a useful tool to investigate the connectivity structure of mental health disorders. In the case of major depressive disorder (MDD), recent studies regarding the RS-fMRI have found abnormal connectivity in several regions of the brain, particularly in the default mode network (DMN). Thus, the relevance of the DMN to self-referential thoughts and ruminations has made the use of the resting-state approach particularly important for MDD. The majority of such research has relied on the grand averaged functional connectivity measures based on the temporal correlations between the BOLD time series of various brain regions. We, in our study, investigated the variations in the functional connectivity over time at global and local level using RS-fMRI BOLD time series of 27 MDD patients and 27 healthy control subjects. We found that global synchronization and temporal stability were significantly increased in the MDD patients. Furthermore, the participants with MDD showed significantly increased overall average (static) functional connectivity (sFC) but decreased variability of functional connectivity (vFC) within specific networks. Static FC increased to predominance among the regions pertaining to the default mode network (DMN), while the decreased variability of FC was observed in the connections between the DMN and the frontoparietal network.

• 出版日期2016-8