Dimensional assessment of behavioral changes in the cuprizone short-term exposure model for psychosis

作者：Kondo Mari A; Fukudome Daisuke; Smith Dani R; Gallagher Michela; Kamiya Atsushi; Sawa Akira^*

来源：Neuroscience Research, 2016, 107: 70-74.

DOI：10.1016/j.neures.2016.01.006

• Cuprizone
• Cuprizone short-term exposure (CSE)
• Psychosis
• Behavior
• Inflammation
• Hippocampus
• Research Domain Criteria (RDoC)
• Dimensional approach

Recent clinical studies have suggested a role for immune/inflammatory responses in the pathophysiology of psychosis. However, a mechanistic understanding of this process and its application for drug discovery is underdeveloped. Here we assessed our recently developed cuprizone short-term exposure (CSE) mouse model across behavioral domains targeting neurocognitive and neuroaffective systems. We propose that the CSE model may be useful for understanding the mechanism associating inflammation and psychosis, with applications for drug discovery in that context.

• 出版日期2016-6