A highly selective magnetic sensor for Cd2+ in living cells with (Zn, Mn)-doped iron oxide nanoparticles

作者：Zhang, Yang; Shen, Jinchao; Yang, Hong^*; Yang, Yan; Zhou, Zhiguo; Yang, Shiping

来源：Sensors and Actuators B: Chemical , 2015, 207(PartA): 887-892.

DOI：10.1016/j.snb.2014.10.074

• Magnetic sensor
• Cd2+
• Living cells
• Nanoparticles

A magnetic sensor for Cd2+ has been developed based on (Zn, Mn)-doped iron oxide nanoparticles [(Zn, Mn) Fe(3)O(4)NPs], which was modified by ethyl 1-(2-(3',4'-dihydroxyphenyl)-2-oxoethyl)-1H-1,2,3-triazole-4-carboxylate (ETC). ETC provided the binding sites to Cd2+ to induce the transformation of (Zn, Mn) Fe(3)O(4)NPs from a dispersed to an aggregated state with a corresponding increase in the transverserelaxation time (T-2) of surrounding water protons. Owing to the special strong interaction between ETC and Cd2+, ETC coordinated (Zn, Mn) Fe3O4[(ETC-(Zn, Mn) Fe3O4)] NPs exhibited a low limit of detection of Cd2+ of 3.5 nM and a high selectivity over other metal ions. Furthermore, ETC-(Zn, Mn) Fe(3)O(4)NPs can be used to detect Cd2+ in living cells by magnetic resonance (MR) imaging.

• 出版日期2015-2
• 单位上海师范大学; 上海交通大学