Asymmetric Mannich reactions catalyzed by cinchona alkaloid thiourea: enantioselective one-pot synthesis of novel beta-amino ester derivatives

作者：Bai, Song; Liang, Xueping; Song, Baoan; Bhadury, Pinaki S.; Hu, Deyu; Yang, Song

来源：Tetrahedron: Asymmetry , 2011, 22(5): 518-523.

DOI：10.1016/j.tetasy.2011.02.029

• AZA-HENRY REACTION
• DYNAMIC KINETIC RESOLUTION
• CHIRAL LEWIS-BASE
• CONJUGATE ADDITION
• STRECKER REACTION
• N-BOC
• BIFUNCTIONAL ORGANOCATALYSTS
• STEREOSELECTIVE-SYNTHESIS
• ACYL IMINES
• KETO-ESTERS

An efficient one-pot synthesis of novel beta-amino ester derivatives containing a benzoxazol moiety has been developed by using cinchona alkaloid thioureas as the organocatalyst. The adducts were isolated in high enantiomeric excess and high yield.

• 出版日期2011-3-8
• 单位贵州大学