Decreased plasma neurotrophin-4/5 levels in bipolar disorder patients in mania

作者：Barbosa Izabela G^*; Morato Isabela B; Huguet Rodrigo B; Rocha Fabio L; Machado Vieira Rodrigo; Teixeira Antonio L

来源：Brazilian Journal of Psychiatry, 2014, 36(4): 340-343.

DOI：10.1590/1516-4446-2014-1380

• Neurotrophin
• mania
• depression
• bipolar disorder
• biomarker

Objective: To evaluate two poorly explored neurotrophins (NT), NT-3 and NT-4/5, in bipolar disorder (BD). %26lt;br%26gt;Methods: Forty patients with type I BD (18 in remission and 22 in mania) and 25 healthy controls matched for age, gender, and educational attainment were enrolled in this study. All subjects were assessed by the Mini-International Neuropsychiatric Interview; the Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to evaluate severity of symptoms in BD patients. Plasma levels of NT-3 and NT-4/5 were measured by enzyme-linked immunosorbent assay (ELISA). %26lt;br%26gt;Results: BD patients in mania presented decreased NT-4/5 plasma levels in comparison with controls (p%26lt;.05). There were no significant differences in NT-3 plasma levels between BD patients and controls. %26lt;br%26gt;Conclusion: These findings corroborate the view that neurotrophin dysfunction is associated with mood states in patients with BD.

• 出版日期2014-12