New Synthesis of Brivudine and Its Analogs

作者:Li Peiyuan*; Zhang Jianrui; Guo Shenghai; Zhang Xinying; Fan Xuesen
来源:Chinese Journal of Organic Chemistry, 2015, 35(4): 910-916.
DOI:10.6023/cjoc201410034

摘要

In this paper, a simple and practical method for the preparation of brivudine (BVDU) and its analog nucleoside derivatives via condensation of the easily obtainable 5-formyl pyrimidine nucleosides with carbon tetrabromide followed by an efficient and stereoselective debromination promoted by diethyl phosphite and triethylamine is presented.