New autoantibodies and their clinical associations in juvenile myositis - a systematic review

作者：Peixoto Daniela^*; Costa Jose; Ferretti Marta; Malattia Clara; Martini Alberto

来源：Acta Reumatologica Portuguesa, 2013, 38(4): 234-241.

• Myositis-specific antibodies
• Novel autoantibodies
• Juvenil idiopathic inflammatory myopathies

Background: Novel autoantibodies targeting intracellular proteins are recently detected in patients with idiopathic inflammatory myopathies (IIMs). %26lt;br%26gt;Objective. To evaluate the prevalence of these myositis-specific antibodies (MSAs) in juvenile IIMs and their association with clinical characteristics and disease course. %26lt;br%26gt;Methods: A systematic literature search was carried out to identify all studies concerning these novel MSAs (p155/140, p140, CADM-140, SAE and 200/100) in patients with JIIMs. Results: A total of 1003 references were identified, of which 118 were selected for detailed analysis and 13 included in the final review. %26lt;br%26gt;Conclusions: The anti-p155/140, the anti-p140 and the anti-CADM-140 seem to be useful markers for define distinct clinical subsets and for predicting prognosis of JIIMs. Further studies are needed to clarify the importance of anti 200/100 and anti-SAE in juvenile myositis.

• 出版日期2013-12