科研之友
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摘要
Using coarse-grained molecular dynamics simulations we have explored the effect of a-Synuclein (alpha Syn) on the structural and mechanical properties of small unilamellar vesicles in the fluid-phase. The study is motivated by observations that a high density of membrane-bound alpha Syn inhibits the fusion of synthetic small unilamellar vesicles. By combining three-dimensional pressure tensor calculations with our recently developed spherical harmonics fluctuation analysis approach, we show a reduction in membrane surface tension and increased membrane undulations when alpha Syn is bound to the vesicle's outer leaflet at a 200: 1 L/P. The protein effects these changes by decreasing the negative pressure in the headgroup region of the outer leaflet and increasing the positive pressure throughout the hydrocarbon core.
- 出版日期2015-4-21
