A new antifungal briarane diterpenoid from the gorgonian Junceella juncea Pallas

作者：Murthy Y L N^*; Mallika D; Rajack Abdul; Reddy G Damodar

来源：Bioorganic & Medicinal Chemistry Letters, 2011, 21(24): 7522-7525.

DOI：10.1016/j.bmcl.2011.06.087

• Junceella juncea
• Briarane
• Antifungal activity

A new 8-hydroxy briarane diterpenoid (compound 1) with antifungal activity was isolated along with known compounds (2-5) from the gorgonian coral Junceella juncea. On the basis of spectroscopic data (1D and 2D NMR, MS), the structure of the compound 1 was established as (1S,2S,8S,9S,10S, 11R,12R,14S,17R)-11,20-epoxy-14-(3-methylbutanoyl)-2,9,12-triacetoxy-8-hydroxybriar-5(16)-en-18,7-olide. Compound 1 exhibited significant activity against fungi (Aspergillus niger, Candida albicans and Penicillium notatum) but the other compounds (2-5) did not exhibit the activity against fungi.

• 出版日期2011-12-15