A SERS substrate of mesoporous g-C3N4 embedded with in situ grown gold nanoparticles for sensitive detection of 6-thioguanine

作者：Wang, Ya-Ning; Zhang, Ying; Zhang, Wen-Shu; Xu, Zhang-Run^*

来源：Sensors and Actuators B: Chemical , 2018, 260: 400-407.

DOI：10.1016/j.snb.2017.12.173

• Mesoporous graphitic carbon nitride
• SERS
• 6-thioguanine
• Chemical enhancement
• High sensitivity

A novel surface-enhanced Raman scattering substrate was developed through in situ growing gold nanoparticles inside the mesoporous graphitic carbon nitride with a large surface area. The mesoporous structure afforded support for loading more gold nanoparticles, defined the nanoparticle diameter and ensured uniform distribution of the nanoparticles. Crystal violet used as a Raman probe was detected by SERS based on the hybrids with an enhancement factor of 5.0 x 10(5), and the relative standard deviation of the peak intensity (at 1174 cm(-1) and 1618 cm(-1)) were 6.2% and 6.1% (n = 30) for solid samples, and 5.1% and 5.0% (n = 11) for liquid samples. The high SERS activity was attributed to abundant hot spots formed by high-density gold nanoparticles and chemical enhancement from mpg-C3N4, and the good reproducibility was due to controlled size and uniform distribution of the gold nanoparticles. An antineoplastic drug, 6-thioguanine was detected with a wide linear range from 0.60 mu M to 48 mu M and a low detection limit of 0.24 mu M. The mesoporous g-C3N4 embedded with gold nanoparticles significantly improved the SERS sensitivity and reproducibility for 6-thioguanine detection, and it holds promising potential in noninvasive and ultrasensitive drug monitoring.

• 出版日期2018-5-1
• 单位东北大学