MRI estimation of gadolinium and albumin effects on water proton

作者：Bagher Ebadian Hassan^*; Paudyal Ramesh; Nagaraja Tavarekere N; Croxen Richard L; Fenstermacher Joseph D; Ewing James R

来源：NeuroImage, 2011, 54: S176-S179.

DOI：10.1016/j.neuroimage.2010.05.032

• Longitudinal relaxation time
• Longitudinal relaxivity
• Water proton
• Contrast agents

The longitudinal relaxivity on the protons of water of a Gd-chelate-albumin compound was measured at 7 T as a function of the macromolecular content of a cross-linked matrix. In agreement with previous works, the results demonstrate that the effect of gadolinium on water proton relaxivity is not constant, rising moderately with increase in the concentration of bovine serum albumin (BSA). About 35% variation in relaxivity was observed over a 0%-25% range of BSA concentrations (R = 3.893 + 0.0502 x BSA [%], SE-.0119 and 0.1740, t-4.215 and 22.383, p<0.014 and 0.001).

• 出版日期2011-1