A structural perspective on protein-protein interactions

作者:Russell RB*; Alber F; Aloy P; Davis FP; Korkin D; Pichaud M; Topf M; Sali A
来源:Current Opinion in Structural Biology, 2004, 14(3): 313-324.
DOI:10.1016/j.sbi.2004.04.006

摘要

Structures of macromolecular complexes are necessary for a mechanistic description of biochemical and cellular processes. They can be solved by experimental methods, such as X-ray crystallography, NMR spectroscopy and electron microscopy, as well as by computational protein structure prediction, docking and bioinformatics. Recent advances and applications of these methods emphasize the need for hybrid approaches that combine a variety of data to achieve better efficiency, accuracy, resolution and completeness.

  • 出版日期2004-6