Mechanism of K+/Na+ selectivity in potassium channels from the perspective of the non-selective bacterial channel NaK

作者：Durdagi Serdar; Noskov Sergei Y^*

来源：Channels, 2011, 5(3): 198-200.

DOI：10.4161/chan.5.3.15873

• NaK
• CNG channels mimetic
• ion selectivity
• tetrameric cation channels

Studies of the non-selective NaK channel as a model system provided detailed structural and functional insights into different factors that modulate selective ion conductance. The combination of structural and functional studies of WT- and mutant forms of NaK channel show that apparent conservation of the multiple binding sites in the canonical selectivity filter of K-channel is essential component of the observed robust Na+ discrimination.

• 出版日期2011-6