Ammonium Dihydrogen Phosphate Catalyst for One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones

作者：Tayebee Reza^*; Maleki Behrooz; Ghadamgahi Malihe

来源：Chinese Journal of Catalysis, 2012, 33(4): 659-665.

DOI：10.1016/S1872-2067(11)60355-0

• 3,4-dihydropyrimidin-2-(1H)-one
• ammonium dihydrogen phosphate
• solvent free
• condensation

A one-pot three component Biginelli condensation of different substituted aromatic and aliphatic aldehydes with ethyl acetoacetate and urea to the respective 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions that is simple, effective, and environmentally friendly was shown. Ammonium dihydrogen phosphate (NH4H2PO4) was used as a non-toxic, inexpensive, and easily available catalyst. The facile reaction condition and simple isolation and purification procedures of this method make it a good option for the synthesis of dihydropyrimidinones.

• 出版日期2012-4