Dependence on the CCR5 Coreceptor for Viral Replication Explains the Lack of Rebound of CXCR4-Predicted HIV Variants in the Berlin Patient

作者：Symons Jori; Vandekerckhove Linos; Hutter Gero; Wensing Annemarie M J; van Ham Petra M; Deeks Steven G; Nijhuis Monique^*

来源：Clinical Infectious Diseases, 2014, 59(4): 596-600.

DOI：10.1093/cid/ciu284

• HIV
• cure
• Berlin-Patient
• coreceptor
• stem cell transplantation

The "Berlin patient" is the first patient cured of HIV-1 infection after allogeneic transplantation with nonfunctional CCR5 coreceptor stem cells. We demonstrate that CXCR4-predicted minority viruses present prior to transplantation were unable to rebound after transplantation due to their dependence on CCR5 for replication and high genetic barrier toward CXCR4 usage.

• 出版日期2014-8-15