Donor Exposures in Recipients of Pooled Platelet Concentrates: a Case-Study in Arithmetic, Logic, %26quot;Expert Opinion%26quot;, and the %26quot;Peer Review%26quot; Process

作者：Vamvakas E C^*; Hitzler W E

来源：Clinical Laboratory, 2013, 59(3-4): 415-420.

DOI：10.7754/Clin.Lab.2013.130305

Advocacy for single-donor (rather than pooled) platelets has been based on the absolute increase in the risk of transfusion-transmitted infections (TTIs) from pooled (rather than single-donor) platelets in the population of platelet transfusion recipients. A recent study published in a prestigious medical journal advocated for pooled (rather than single-donor) platelets based on the relative increase in the risk of TTIs from pooled (rather than single-donor) platelets in patients transfused with any blood component. If this policy recommendation for use of pooled (rather than single-donor) platelets were followed in the US, there would be an annual increase in the risk of TTIs by 15-20 recipient infections for hepatitis B virus, 85-113 recipient infections for the next %26quot;West-Nile-virus-like%26quot; pathogen, and 528-704 recipient infections for the next %26quot;human-immunodeficiency-virus-like%26quot; pathogen to emerge in the future. We present the calculation of the increased risk and discuss the stark contrast between simple arithmetic and logic versus the end result of a process of %26quot;expert opinion%26quot; and %26quot;peer review%26quot;.

• 出版日期2013