Anti-inflammatory Anthraquinones from the Crinoid Himerometra magnipinna

作者:Lin, Yen You; Tsai, Su June; Chiang, Michael Y; Wen, Zhi Hong*; Su, Jui Hsin
来源:Natural Product Communications, 2015, 10(2): 317-318.
DOI:10.1177/1934578x1501000227

摘要

Chemical investigation of a crinoid Himerometra magnipinna has afforded three anthraquinones (1-3), including one new metabolite, ( )-rhodoptilometrin (1). The structures of these compounds were elucidated on the basis of their spectroscopic data and the absolute configuration of 1 was further confirmed by single-crystal X-ray diffraction analysis. In the in vitro anti-inflammatory effects test, compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the LPS-stimulated RAW264.7 macrophage cells.

全文