Multiscale Entropy Analysis of Pulse Wave Velocity for Assessing Atherosclerosis in the Aged and Diabetic

作者：Wu Hsien Tsai^*; Hsu Po Chun; Lin Cheng Feng; Wang Hou Jun; Sun Cheuk Kwan; Liu An Bang; Lo Men Tzung; Tang Chieh Ju

来源：IEEE Transactions on Biomedical Engineering, 2011, 58(10): 2978-2981.

DOI：10.1109/TBME.2011.2159975

• Atherosclerosis
• diabetic
• dynamic parameter
• multiscale entropy (MSE)
• pulse wave velocity (PWV)

This study proposed a dynamic pulse wave velocity (PWV)-based biomedical parameter in assessing the degree of atherosclerosis for the aged and diabetic populations. Totally, 91 subjects were recruited from a single medical institution between July 2009 and October 2010. The subjects were divided into four groups: young healthy adults (Group 1, n = 22), healthy upper middle-aged adults (Group 2, n = 28), type 2 diabetics with satisfactory blood sugar control (Group 3, n = 21), and unsatisfactory blood sugar control (Group 4, n = 20). A self-developed six-channel electrocardiography (ECG)-PWV-based equipment was used to acquire 1000 successive recordings of PWV(foot) values within 30 min. The data, thus, obtained were analyzed with multiscale entropy (MSE). Large-scale MSE index (MEI(LS)) was chosen as the assessment parameter. Not only did MEI(LS) successfully differentiate between subjects in Groups 1 and 2, but it also showed a significant difference between Groups 3 and 4. Compared with the conventional parameter of PWV(foot) and MEI on R-R interval [i.e., MEI (RRI)] in evaluating the degree of atherosclerotic change, the dynamic parameter, MEI(LS) (PWV), could better reflect the impact of age and blood sugar control on the progression of atherosclerosis.

• 出版日期2011-10
• 单位中央民族大学; 东华大学