Activation and Migration of Adventitial Fibroblasts Contributes to Vascular Remodeling

作者：Han, Xiaowan; Wu, Aiming; Wang, Jie; Chang, Hong; Zhao, Yizhou; Zhang, Yan; Mao, Yingqiu; Lou, Lixia; Gao, Yonghong; Zhang, Dongmei; Li, Tong; Yang, Tao; Wang, Lei; Feng, Cuiling^*; Zhao, Mingjing^*

来源：Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology, 2018, 301(7): 1216-1223.

DOI：10.1002/ar.23793

• adventitial fibroblasts
• migration
• vascular remodeling

The rat carotid artery balloon injury model was used to prove the activation and migration of adventitial fibroblasts. We found that at day 7 after injury, adventitial fibroblasts proliferated, transformed into myofibroblasts under transmission electron microscopy in the model group. Simultaneously, we proved that the adventitial cells migrated to the media and intima on seventh day after injury by directly labeled the adventitial cells by the in vivo gene transfer technique. Moreover, we captured the precise moment when the adventitial fibroblasts migrated from the adventitia to the media through the external elastic plate under transmission electron microscope. This study provides direct evidences that adventitial fibroblasts activate and migrate to the media and intima, then actively take part in revascularization.

• 出版日期2018-7
• 单位中国人民解放军总医院; 北京中医药大学; 北京大学