Microwave-assisted facile synthesis of [a]-annelated pyrazolopyrroloindoles via intramolecular azomethine imine 1,3-dipolar cycloaddition

作者：Shinde Anand H; Vidyacharan Shinde; Sharada Duddu S^*

来源：Tetrahedron Letters, 2014, 55(19): 3064-3069.

DOI：10.1016/j.tetlet.2014.03.134

• Microwave-assisted
• 1,3-Dipolar cycloaddition
• Azomethine imine
• Pyrazolopyrroloindole
• Stereoselective

The synthesis of [a]-annelated pyrazolopyrroloindoles via intramolecular 1,3-dipolar cycloaddition of in situ generated azomethine imine from N-allylated indole-2-carboxaldehyde, in regio- and stereoselective manner by using microwave irradiation is described. A one-pot strategy for the expedient synthesis of pyrazolopyrroloindoles has been developed.

• 出版日期2014-5-7