Preparation and study on the solid inclusion complex of sparfloxacin with beta-cyclodextrin

作者：Chao JB^*; Tong HB; Huang SP; Liu DS

来源：Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2004, 60(1-2): 161-166.

DOI：10.1016/S1386-1425(03)00211-7

• sparfloxacin
• beta-CD
• inclusion complex
• 1D NMR
• 2D NMR

The interaction of sparfloxacin with beta-cyclodextrin (beta-CD) has been studied by several analytical techniques, including H-1-NMR, C-13-NMR, fluorescence spectroscopy, infrared spectroscopy, thermal analysis, and scanning electron microscope. In this paper, solid inclusion complex of sparfloxacin with beta-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, Infrared, differential scanning calorimetry and 1D, 2D NMR. The experimental results confirmed the existence of l: l inclusion complex of sparfloxacin with beta-CD. The formation constant of complex was determined by fluorescence method and H-1-NMR. Spacial configuration of complex has been proposed on 2D NMR techniques.

• 出版日期2004-1
• 单位山西大学