A new flavonol glycoside from the medicinal halophyte Suaeda fruticosa

作者：Oueslati Samia^*; Ksouri Riadh; Pichette Andre; Lavoie Serge; Girard Lalancette Karl; Mshvildadze Vakhtang; Abdelly Chedly; Legault Jean

来源：Natural Product Research, 2014, 28(13): 960-966.

DOI：10.1080/14786419.2014.900771

• flavonol glycoside
• high-performance liquid chromatography
• mass spectrometry
• nuclear magnetic resonance
• Suaeda fruticosa
• oxygen radical absorbance capacity

A new flavonol glycoside, namely 3-(alpha-rhamnopyranosyl-(1 -> 2)-[beta-xylopyranosyl-(1 -> 6)]-beta-glucopyranosyloxy) isorhamnetin was reported from methanol extracts of aerial parts of Suaeda fruticosa for the first time. In this work, liquid chromatography coupled to atmospheric pressure chemical ionisation mass spectrometry, high-resolution mass spectrometry and nuclear magnetic resonance spectroscopy were used to identify this new compound. Structure was elucidated on the basis of extensive spectroscopic analysis, including HSQC, HMBC and H-1-H-1 COSY. Antioxidant potentialities of a pure compound were evaluated. The estimation of antioxidant capacities using oxygen radical absorbance capacity (ORAC method) and a cell based-assay (WS1) indicated that this new flavonol exhibited the highest antioxidant activities with an ORAC value of 5.0 +/- 0.3 mu mol Trolox/mu mol and inhibited the t BH-induced oxidation of 2',7'-dichlorofluorescin with an IC50 value of 4.9 +/- 0.6 mu M.

• 出版日期2014