Amerindian Genetic Ancestry Protects against Alzheimer%26apos;s Disease

作者：Benedet Andrea L; Moraes Clayton F; Camargos Einstein F; Oliveira Larissa F; Souza Vincius C; Lins Tulio C; Henriques Adriane D; Carmo Dayanne G S; Machado Silva Wilcelly; Arauje Carla Nunes; Cordova Claudio; Pereira Rinaldo W; Nobrega Otavio T^*

来源：Dementia and Geriatric Cognitive Disorders, 2012, 33(5): 311-317.

DOI：10.1159/000339672

• Alzheimer%26apos
• s disease
• Dementia
• Genetic ancestry
• Ancestry markers
• Continental population
• Admixture
• Complex disease

Background: Alzheimer%26apos;s disease (AD) is the most common form of dementia worldwide, and bears remarkable evidence for a differential prevalence among continental populations. In this scenario, estimating ancestry proportions in recently admixed populations is a strategy that can help increasing knowledge about the genetic structure of this complex trait. Aim/Methods: Our purpose was to assess mean ancestry estimates for the three main parental contributors to the Brazilian contingent (European, African and Amerindian) using a panel of 12 ancestry informative markers. Outpatients with the late-onset form of AD (n = 120) were compared for ancestry levels with non-cognitively impaired subjects (n = 412) in the Midwest Brazil, controlling for classic clinical, social and anthropometric risk factors. Results: Our findings show a 3-fold greater genetic Amerindian content among control subjects compared to AD patients (p %26lt; 0.001). Conclusion: Our results suggest that the allelic architecture of Native Americans can confer protection against the onset of the disease.

• 出版日期2012