A case of human infection with avian Influenza A/H7N9 virus in Beijing: virological and serological analysis

作者：Pan Yang; Shi Weixian; Yang Peng; Wu Shuangsheng; Peng Xiaomin; Cui Shujian; Zhang Daitao; Lu Guilan; Zhao Jiachen; Liu Yimeng; Wang Quanyi^*

来源：Journal of Infection in Developing Countries, 2015, 9(3): 317-320.

DOI：10.3855/jidc.5875

• Influenza
• H7N9 avian influenza
• drug resistance
• antibody
• viral load

This study described some essential viral and sera-characteristics of A/H7N9 virus infection in a 61-year old case patient. With the antiviral therapy and respiratory support, the patient showed a significant decrease of viral loads from 6.72 log(10) copies/mL to 0 in 22 days, and a correlated increase of serum hemagglutination inhibition titers during the same period. Phylogenetic analysis demonstrated that the isolated strain was highly homologous to previous strains isolated in the southeast of China. Drug resistance-associated R292K mutation became detectable 17 days after antiviral therapy, but no remarkable influence on the viral clearance was observed.

• 出版日期2015-3